Hyland OnBase vs MasterControl Comparison: Reviews, Features, Pricing & Alternatives in 2026

Detailed side-by-side comparison to help you choose the right solution for your team

Updated May 2026 8 min read

Hyland OnBase

0.0 (0 reviews)

Hyland OnBase is a unified enterprise information platform that combines document management, case management, and business process automation to help you centralize your critical content and streamline your daily workflows.

Starting at --
Free Trial NO FREE TRIAL
VS

MasterControl

0.0 (0 reviews)

MasterControl provides a unified manufacturing and quality management software platform to help life sciences companies deliver safer, more effective products to patients faster and more reliably.

Starting at --
Free Trial NO FREE TRIAL

Quick Comparison

Feature Hyland OnBase MasterControl
Website hyland.com mastercontrol.com
Pricing Model Custom Custom
Starting Price Custom Pricing Custom Pricing
FREE Trial ✘ No free trial ✘ No free trial
Free Plan ✘ No free plan ✘ No free plan
Product Demo ✓ Request demo here ✓ Request demo here
Deployment saas on-premise mobile desktop saas cloud
Integrations Microsoft Office Salesforce SAP Oracle Workday Epic Esri Microsoft Dynamics Outlook Adobe Acrobat SAP Oracle Microsoft Dynamics Salesforce Workday MuleSoft
Target Users mid-market enterprise mid-market enterprise
Target Industries healthcare government financial-services healthcare manufacturing biotechnology
Customer Count 0 0
Founded Year 1991 1993
Headquarters Westlake, USA Salt Lake City, USA

Overview

H

Hyland OnBase

Hyland OnBase helps you manage your entire world of information by centralizing your documents, data, and processes in one secure location. You can eliminate manual data entry and paper-based bottlenecks by capturing information at its source and routing it automatically to the right people. It acts as a single point of truth for your organization, ensuring that you always have the most current version of a file exactly when you need it.

The platform is designed for mid-market and enterprise organizations across highly regulated sectors like healthcare, government, and financial services. You can use it to automate complex case management tasks, ensure regulatory compliance with automated retention policies, and integrate your content directly with your existing ERP or CRM systems. It scales with your growth, allowing you to start with a single department and expand across your entire enterprise as your needs evolve.

strtoupper($product2['name'][0])

MasterControl

MasterControl helps you bridge the gap between quality and manufacturing by digitizing your entire product lifecycle. You can eliminate paper-based processes and manual data entry, which reduces the risk of human error and ensures you stay compliant with rigorous FDA and ISO standards. The platform connects your documents, training records, and quality events in a single location so your team always works from the most current information.

You can accelerate your production timelines by using digital production records that catch errors in real-time rather than after a batch is completed. Whether you are a growing biotech startup or a global pharmaceutical leader, the software scales to meet your specific regulatory needs. By integrating quality directly into the manufacturing process, you can focus more on innovation and less on administrative paperwork.

Overview

H

Hyland OnBase Features

  • Intelligent Capture Capture documents and data automatically from scanners, emails, or mobile devices to eliminate manual data entry errors.
  • Workflow Automation Route documents through your custom business processes automatically to speed up approvals and reduce operational delays.
  • Dynamic Case Management Manage complex processes that require human judgment by viewing all related data, tasks, and conversations in one place.
  • Native Integrations Access your documents directly within the applications you use every day, like Microsoft Office, SAP, or Salesforce.
  • Records Management Automate your document retention and destruction schedules to stay compliant with industry regulations and legal requirements.
  • Mobile Access Review documents and approve workflows from your smartphone or tablet while you are away from your desk.
strtoupper($product2['name'][0])

MasterControl Features

  • Document Control. Automate your entire document lifecycle from routing and escalation to approval and archiving in a secure, centralized system.
  • Training Management. Automate the assignment and monitoring of training tasks to ensure your personnel are always compliant with current SOPs.
  • CAPA Automation. Integrate your corrective and preventive actions with the rest of your quality system to identify and resolve issues faster.
  • Audit Management. Streamline your internal and external audit processes with automated scheduling, customizable checklists, and real-time tracking of findings.
  • Change Control. Manage changes to processes or products with a structured workflow that ensures all stakeholders review and approve modifications.
  • Digital Production Records. Replace paper batch records with digital versions that validate data entry in real-time to prevent production errors.

Pricing Comparison

H

Hyland OnBase Pricing

M

MasterControl Pricing

Pros & Cons

M

Hyland OnBase

Pros

  • Highly customizable to fit unique industry business processes
  • Deep integration capabilities with existing enterprise software systems
  • Strong security features and granular user access controls
  • Reliable performance even when managing millions of documents

Cons

  • Significant time investment required for initial system setup
  • Administrator training is necessary due to platform complexity
  • Upgrading to newer versions can be a resource-intensive process
A

MasterControl

Pros

  • Simplifies complex regulatory compliance for FDA and ISO
  • Centralizes all quality documents in one searchable location
  • Automates repetitive follow-ups for training and tasks
  • Strong audit trail capabilities for high-stakes environments

Cons

  • Initial configuration requires significant time and effort
  • Interface can feel overwhelming for occasional users
  • System performance can lag with very large datasets
x

Please claim profile in order to edit product details and view analytics. Provide your work email address to receive a verification link.

x

Please login in order to edit product details and view analytics.