Cisco ISE vs Infoblox Comparison: Reviews, Features, Pricing & Alternatives in 2026

Detailed side-by-side comparison to help you choose the right solution for your team

Updated Apr 2026 8 min read

Cisco ISE

0.0 (0 reviews)

Cisco Identity Services Engine is a network administration product that enables you to create and enforce security policies for users and devices connecting to your organization's network infrastructure.

Starting at --
Free Trial 90 days
VS

Infoblox

0.0 (0 reviews)

Infoblox provides a unified networking and security platform that uses DNS-layer data to protect your organization from cyber threats while simplifying cloud-managed network connectivity and visibility.

Starting at --
Free Trial 30 days

Quick Comparison

Feature Cisco ISE Infoblox
Website cisco.com infoblox.com
Pricing Model Custom Custom
Starting Price Custom Pricing Custom Pricing
FREE Trial ✓ 90 days free trial ✓ 30 days free trial
Free Plan ✘ No free plan ✘ No free plan
Product Demo ✓ Request demo here ✓ Request demo here
Deployment saas on-premise saas on-premise
Integrations Cisco DNA Center Splunk ServiceNow Microsoft Azure AD Okta Check Point Palo Alto Networks Rapid7 Tenable Qualys Splunk ServiceNow Cisco Palo Alto Networks CrowdStrike Microsoft Azure AWS Google Cloud Platform Tenable Qualys
Target Users mid-market enterprise mid-market enterprise
Target Industries
Customer Count 0 0
Founded Year 1984 1999
Headquarters San Jose, USA Santa Clara, USA

Overview

C

Cisco ISE

Cisco Identity Services Engine (ISE) gives you a centralized way to manage security across your entire network. You can see exactly who and what is connecting to your environment, whether they are using a wired, wireless, or VPN connection. By gathering real-time data from users and devices, you can make informed decisions about who gets access to specific resources and under what conditions.

You can automate your network security by creating granular policies that adapt based on the user's role, device type, and location. This helps you stop threats before they spread by automatically isolating suspicious devices. Whether you are managing a corporate office or a distributed workforce, it provides the visibility you need to maintain a zero-trust security posture without slowing down your team.

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Infoblox

Infoblox provides a centralized platform to manage your critical network services—DNS, DHCP, and IP address management (collectively known as DDI). By moving these services to a unified cloud-managed interface, you eliminate the manual effort of tracking IP addresses in spreadsheets and reduce the risk of network downtime. You can gain full visibility into every device connecting to your network, whether they are in your main office, a remote branch, or a cloud environment.

Beyond connectivity, you can use the platform to turn your DNS into a security asset. It automatically blocks connections to known malicious domains and detects data exfiltration attempts that traditional firewalls often miss. This proactive approach helps you stop threats earlier in the kill chain. The software is designed for mid-to-large organizations that need to maintain high availability and consistent security policies across complex, distributed global infrastructures.

Overview

C

Cisco ISE Features

  • AI Endpoint Analytics Identify and profile every device on your network automatically using AI-driven behavioral modeling to eliminate blind spots.
  • Zero Trust Access Enforce software-defined segmentation to ensure you only grant users access to the specific applications they need for work.
  • Automated Containment Block or quarantine compromised devices instantly through integrations with your security tools to prevent lateral movement of threats.
  • Guest Access Management Create custom web portals for your visitors to provide secure, time-limited internet access without compromising your internal data.
  • Compliance Monitoring Check the security posture of every device before it connects to ensure they meet your corporate encryption and antivirus standards.
  • Centralized Policy Management Define your security rules once and push them across your entire global network from a single, unified management console.
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Infoblox Features

  • Unified DDI Management. Manage DNS, DHCP, and IP addresses from one console to ensure consistent connectivity across your entire enterprise.
  • BloxOne Threat Defense. Protect your devices everywhere by using DNS-level intelligence to block malicious lookups and prevent data theft.
  • Automated IPAM. Eliminate manual errors by automatically discovering and tracking every IP address across your physical and cloud networks.
  • Lookalike Domain Detection. Identify and block fraudulent domains that mimic your brand to protect your employees from sophisticated phishing attacks.
  • Ecosystem Integration. Share real-time security data with your existing tools like SIEMs and SOARs to speed up incident response.
  • Cloud-Native Deployment. Deploy network services as microservices in the cloud to scale your infrastructure instantly without adding hardware.

Pricing Comparison

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Cisco ISE Pricing

I

Infoblox Pricing

Pros & Cons

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Cisco ISE

Pros

  • Unmatched visibility into every device connected to your network
  • Granular policy control for complex enterprise environments
  • Seamless integration with the broader Cisco security ecosystem
  • Powerful automation for isolating and remediating infected endpoints
  • Highly scalable for global organizations with thousands of users

Cons

  • Significant learning curve for initial setup and configuration
  • Requires substantial hardware resources for on-premise deployments
  • Licensing structure can be complex to navigate and manage
A

Infoblox

Pros

  • Extremely reliable DNS and DHCP services for high-uptime environments
  • Centralized visibility across hybrid and multi-cloud infrastructures
  • Powerful automation reduces manual IP management tasks significantly
  • Effective at blocking threats before they reach the network
  • Detailed reporting helps with compliance and audit requirements

Cons

  • Significant learning curve for new administrators
  • Premium pricing makes it expensive for smaller organizations
  • User interface can feel complex and overwhelming initially
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